One of the main functions of mitochondria is the generation of ATP. To this end, protein complexes of the respiration chain, e.g. ATP synthase, must be inserted into the mitochondrial membrane. Most mitochondrial proteins are translated in the host cytoplasm from nuclear encoded mRNAs and delivered to mitochondria by targeting sequences. This project addresses how mitochondrial energy metabolism is linked to intracellular logistics and other intracellular entities such as endosomes in U. maydis. In particular, we will combine optogenetics, biosensors, microfluidics and modelling to uncover how endosomal transport of mRNAs encoding mitochondrial proteins orchestrates subcellular mitochondrial metabolism. Thereby, we will deepen our understanding how an organelle of endosymbiontic origin is integrated in the intracellular networking.
Prof. Dr. Michael Feldbrügge
Institutsleitung +49 211 81-15475
Institute of Microbiology
Universitätsstr. 1 Gebäude: 26.24.01
Prof. Dr. Matias Zurbriggen
Institutsleitung +49 211 81-15015
Universitätsstr. 1 Gebäude: 26.24