Competition for host nutrients, in particular for carbohydrates, shapes both intra- and interspecies networking. Pathogenic bacteria cause bacterial blight in rice only after inducing sucrose release from host cells, triggered by effector-mediated induction of sucrose uniporter genes. In this project, we will analyse and modulate sugar acquisition and signalling pathways of the bacteria, and the role of nutrition and signalling in intraspecies interactions and the competition between different strains in vitro and during host infection. Key tools are sensors and reporters for metabolites, energy status and signalling intermediates, optogenetic switches, in conjunction with imaging-based analyses in microfluidic platforms to explore spatiotemporal dynamics of organismal interactions.
Prof. Dr. Wolf B. Frommer
Head of Institute +49 211 81-12779
Institute of Molecular Physiology
Universitätsstr. 1 Gebäude: 26.14